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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Luteolin, Erlotinib
Phytochemical Name Luteolin (PubChem CID: 5280445 )
Anticancer drug Name Erlotinib (PubChem CID: 176870 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 63
Ref_1
Pair Name Luteolin, Erlotinib
Disease Info [ICD-11: 2A00] Glioblastoma multiforme Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Up-regulation Expression BAD hsa572
Down-regulation Expression BCL-xL hsa598
Down-regulation Phosphorylation EGFR hsa1956
Down-regulation Phosphorylation MTOR hsa2475
Down-regulation Phosphorylation NFKB1 hsa4790
Up-regulation Cleavage PARP1 hsa142
Down-regulation Phosphorylation STAT3 hsa6774
In Vitro Model U-251MG Astrocytoma Homo sapiens (Human) CVCL_0021
U-87MG ATCC Glioblastoma Homo sapiens (Human) CVCL_0022
Result These findings suggest that combining luteolin with erlotinib offers a potential treatment strategy for glioblastoma multiforme IV.
03. Reference
No. Title Href
1 Luteolin enhances erlotinib's cell proliferation inhibitory and apoptotic effects in glioblastoma cell lines. Front Pharmacol. 2022 Sep 19;13:952169. doi: 10.3389/fphar.2022.952169. Click
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